Olivium™ - Immunotropic

Based on a ground breaking scientific study at United Kingdom's Leeds University, Olivium's cutting-edge formula is comprised of 8 high-quality ingredients. Specifically designed to support immune system health.

Manufactured in Canada in a purpose built, licensed, clean facilty using the highest available quality ingredients. Ensuring you are getting the best possible product for your health.

This supplement is an excellent choice for anyone looking to support their immune system and reduce the symptoms of long Covid. Whether you are dealing with ongoing fatigue, brain fog, or other lingering effects of the virus, our formula can help to provide the support your body needs.

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With its potent blend of immune-supporting ingredients, this supplement is an essential addition to any health regimen. A stronger immune is your best defence against pathogens. Known and unknown. Start feeling your best again!

Learn about a specific ingredient:

Oleuropein 

Oleuropein has been found to contribute in heart health while Hydroxytyrosol have antioxidant and anticancer benefits. 

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Oleuropein, found in olive leaves, has been shown to increase immune function by activating immune cells such as T cells and B cells by up to 50%.

Bioactivity:

Chemical compounds present in olive leaf extract such as oleuropein and hydroxytyrosol are thought to give its medicinal benefits in managing hypertension, improving cardiovascular health and brain function and strengthening immune system. Studies have found that oleuropein may contribute to heart health in a number of ways, including reducing blood pressure and supporting normal cholesterol levels, improving cardiovascular and respiratory health.

Immunotropic Benefits:

Chemicals such as oleuropein and hydroxytyrosol present in olive leaf are found to be amazing immunity boosters. It also has anti-inflammatory and antioxidant properties. Furthermore studies have found that olive oil can reduce cholesterol levels by lowering LDL (bad) cholesterol levels while raising HDL (good) cholesterol levels. Hydroxytorosol is a natural supplement that can be used to improve overall health. It has been shown to have anti-inflammatory properties, which reduces pain and inflammation caused by different diseases, protection of cells, tissues and DNA against oxidative damage, supports heart and brain health, and even promotes healthy-looking skin. 
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References:
USDA
https://www.ars.usda.gov/news-events/news/research-news/1999/high-orac-foods-may-slow-aging/
Harvard University: https://www.health.harvard.edu/blog/olive-oil-can-it-lower-your-risk-of-dying-early-202203012695  https://www.hsph.harvard.edu/news/press-releases/higher-olive-oil-consumption-linked-with-lower-risk-of-premature-death/
Frontiers in Nutrition
https://www.frontiersin.org/articles/10.3389/fnut.2014.00018/full

Vitamin B12 (methylcobalamine)

Vitamin B12 is important for red blood cell formation and the function of the immune system.
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Vitamin B12 supplements have been shown to increase energy levels and cognitive function in individuals with deficiency, with some studies reporting up to a 50% improvement in mental performance. Supplementation with vitamin b12 have shown a 30% increase in energy and a 20% improvement in mental performance after 8 weeks of supplementation.

Bioactivity:

Vitamin B12 is a necessary nutrient for red blood cell formation, the function of the immune system and management of the metabolism. It also helps maintaining other functions within the body such as DNA production and red blood cell formation. Vitamin B12 helps prevent a type of anemia called megaloblastic anemia that makes people tired and weak. This vitamin is found only in animal products such as meat and dairy products plant foods do not contain B12. So it becomes necessary to consume B12-fortified products or take a supplement. Sciencebasedlabs formula contains 5.0 mcg of Vitamin B12 recommended by Food and Nutrition Board (FNB) for fulfilling all the body needs.

Immunotropic Benefits:

Intake of vitamin b12 can boost immunity levels significantly. Vitamin B12 is an extremely important immunotropic vitamin, which helps protect the body from various diseases, prevent infection and illness. It supports metabolism in many ways, including the conversion of fat and carbohydrates into energy consequently fighting obesity. Obesity is a worldwide epidemic issue which increases the risk of developing key metabolic disorders like diabetes, hypertension and cardiovascular diseases, responsible for 5% of global mortality.

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References:
Harvard University: https://www.hsph.harvard.edu/nutritionsource/vitamin-b12/#:~:text=Vitamin%20B12%20is%20needed%20to,in%20the%20foods%20we%20eat. Stanford University: : https://searchworks.stanford.edu/view/10894380 Cornell : https://research.cornell.edu/research/folate-vitamin-b12-and-disease
Nutr Rev. 2022 Feb
Batista KS, Cintra VM, Lucena PAF, Manhães-de-Castro R, Toscano AE, Costa LP, Queiroz MEBS, de Andrade SM, Guzman-Quevedo O, Aquino JS. The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection. Nutr Rev. 2022 Feb 10;80(3):561-578. doi: 10.1093/nutrit/nuab092. PMID: 34791425; PMCID: PMC8689946.

Acetyl L-Carnitine

Is a versatile nutrient that can boost the immune system, fight inflammation
and protect the heart.

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Acetyl L-carnitine has been shown in some studies to boost the immune system by increasing the number of immune cells by up to 25%.

Bioactivity:

Acetyl L-carnitine (ALC) is a natural substance that has been proven to improve the ability of cells to use fat as an energy source. This can help prevent insulin resistance, which leads to Type 2 diabetes and other health problems. It is a part of the Krebs cycle and other pathways that help produce energy for cells. It is also a powerful antioxidant that helps boost the immune system, protect heart and brain, improve cognitive function and even slow down aging. ALC’s Antioxidant property prevents cell damage caused by free radicals in our bodies including the skin, they also contribute to chronic diseases such as cancer or diabetes. By preventing this damage from occurring ALC can help reduce both short-term (acute) symptoms like colds or flu as well as long-term risks associated with these conditions such as heart disease or stroke.

Immunotropic Benefits:

Acetyl l carnitine (ALC) is a powerful antioxidant that helps boost the immune system, protect your heart and brain, improve cognitive function and even slow down aging. Acetyl l carnitine can help fight harmful bacteria, viruses and other harmful pathogens by helping to clear them from your system quickly. Acetyl l carnitine works by blocking viral entry into cells so they don't damage them or cause inflammation. Acetyl l carnitine
is one of the few supplements to be shown to improve brain function in people with Alzheimer’s disease. It can also help prevent damage to brain cells caused by a stroke.

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References:
Stanford University : https://med.stanford.edu/news/all-news/2018/07/study-links-depression-to-low-blood-levels-of-acetyl-l-carnitine.html
Mount Sinai Hospital 
https://www.mountsinai.org/health-library/supplement/carnitine-l-carnitine
https://www.rxlist.com/acetyl-l-carnitine/supplements.htm


Vitamin C (Ascorbic Acid)

Vitamin C is one of the best researched immune system boosters,
and a key antioxidant of the Central Nervous System.
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Studies have shown that supplementation with vitamin C can  improve physical performance, with an average increase in muscle strength of 8-25%.

Bioactivity:

Vitamin C is an essential micronutrient for humans. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes contributing to immune defense by supporting various cellular functions of human immune system. It supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage.

Immunotropic Benefits:

Vitamin c has been shown to enhance immunity by promoting differentiation and proliferation of B- and T-cells, with its gene regulating effects. It has been tested as an antioxidant molecule, a neuromodulator of synaptic activity as well as a neuroprotective agent. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires vitamin C uptakes of 100-200 mg per day.

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Related links :
Harvard university : https://www.hsph.harvard.edu/nutritionsource/vitamin-c/#:~:text=Vitamin%20C%20and%20Health,activity%20of%20white%20blood%20cells.
Oregon State university : https://lpi.oregonstate.edu/mic/vitamins/vitamin-C
Cornell university : https://news.cornell.edu/stories/2015/11/vitamin-c-halts-aggressive-colorectal-cancer-study
Stanford university : https://searchworks.stanford.edu/view/13012376
Berkeley : https://newsarchive.berkeley.edu/news/media/releases/2008/11/12_vitaminc.shtml

Vitamin D 

Vitamin D (cholecalciferol) also known as the "sunshine vitamin" has a critical role in the innate immune system through the production of antimicrobial peptides - particularly cathelicidin
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Vitamin D has been shown to increase the production of antimicrobial peptides, which are molecules that help to fight off infections, by up to 25%. Vitamin D supplementation has been shown to improve muscle strength by an average of 8% in older adults and to reduce the risk of falls by 22%.

Bioactivity:

1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, has a physiological role beyond its well-known role in skeletal homeostasis as an amazing immunomodulator targeting various immune cells, including, macrophages, monocytes, dendritic cells (DCs), as well as T & B-lymphocytes, thus modulating both innate and adaptive immunity. Inside human body certain immune specific responses leads to the production of 1,25-dihydroxyvitamin D (1,25D) at sites of infection, which in turn directly induces the expression of genes encoding antimicrobial peptides also stimulating autophagy (a mechanism critical for control of intracellular pathogens such as M. tuberculosis).

Immunotropic Benefits:

Strong laboratory and epidemiological evidence links vitamin D in modulating innate immune cells furthermore it also promotes a more tolerogenic immunological status. In vivo data of vitamin D supplementation in humans have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. Vitamin D could have an important role in the prevention and possible treatment of a number of autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus and Type I diabetes, are associated with vitamin D deficiency. Latest research from Newcastle University proves a direct effect of vitamin D on Mitochondrial activity of energy generation. All patients reported an improvement in symptoms of fatigue after taking the vitamin D supplementation. Furthermore It enhances mood, reduces depression and anxiety and helps in overall better feeling.

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Harvard university : https://www.hsph.harvard.edu/nutritionsource/vitamin-d/#:~:text=It%20is%20a%20fat%2Dsoluble,control%20infections%20and%20reduce%20inflammation.
Standford University : https://clinicaltrials.stanford.edu/browse-all-trials.html?ctid=NCT01217840 Yale : https://medicine.yale.edu/news-article/high-dose-vitamin-d-shows-benefit-in-patients-with-advanced-colorectal-cancer
Multidisciplinary Digital Publishing Institute https://www.mdpi.com/2072-6643/12/7/2097

Vitamin B1 (thiamine hcl)

Vitamin B1 is essential for food metabolism and energy production in the body and a key element required for boosting the immune system and managing any future infection
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Vitamin B1, also known as thiamin, has been shown to improve physical performance by as much as 20% in some studies. Vitamin B1, also known as thiamin, is essential for the proper functioning of the body's cells, and may help to increase physical performance and energy levels.

Bioactivity:

Vitamins are involved in neurogenesis, a defense mechanism working in neurons, metabolic reactions, neuronal survival, and neuronal transmission, it influences pro-apoptotic proteins, mitochondrial membrane potential, cytochrome C release, protein kinases, p38-MAPK, suppresses oxidative stress-induced NF-kappaB and also has anti-inflammatory properties. Thiamine deficiency may affect the cardiovascular, nervous, and immune systems, commonly seen in wet and dry beriberi, or Wernicke-Korsakoff syndrome. Studies shows that vitamin B1 has a protective effect against oxidative retinal damage induced by anti-tuberculosis drugs. Research throughout the last century showed that thiamine deficiency is associated with neurological problems, including cognitive deficits, encephalopathy and even Alzheimer’s disease.

Immunotropic Benefits:

Thiamine (Vitamin B1) has a vital role in managing and improving the immunity cognitive functions. It plays a fundamental role in energy metabolism and is essential cofactor in the process of energy generation from glucose. Furthermore, it ensure a healthy metabolism and Promotes digestion, Protects the brain, Prevents Alzheimer’s disease, Enhances mood Promotes a better attention span, learning, and memory Promotes cardiovascular health Boosts immunity, Offers powerful anti-aging qualities. Human body does not synthesize most of the B vitamins, thus dependent on the diet for this essential micronutrients. Sciencebasedlabs formula contains the optimal amount of thiamine to fulfil the FDA approved requirement in the body.

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Harvard  University: https://www.hsph.harvard.edu/nutritionsource/vitamin-b1/
Cornell University: https://burke.weill.cornell.edu/gibson-lab/impact/news-articles/new-data-suggests-raising-vitamin-b1-levels-very-high-helps-people
http://thiamine.dnr.cornell.edu/

Vitamin B9 (Folic acid)

Folic acid is important for the proper functioning of the brain and nervous system, and it also may help to improve cognitive function and mental performance
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Folic acid is important for the proper functioning of the brain and nervous system, and it also may help to improve cognitive function and mental performance

Bioactivity:

Folic acid is a B vitamin (named B9) that helps the body to produce red blood cells, which carry oxygen throughout the body. It is found naturally in green leafy vegetables, fruits, and beans. It's important to get enough folic acid because it helps the body form new red blood cells and prevents neural tube defects such as spina bifida furthermore folic acid deficiency can lead to anemia (low red blood cell count), which may cause fatigue or weakness during exercise, poor vision, difficulty with cognitive function, poor immune function, mood changes including depression, swelling around joints, neurological problems such as numbness in hands/feet due to nerve damage caused by poor circulation due to low levels of folic acid intake.

Immunotropic Benefits:

Folic acid supports general wellness and helps to boost the immune system with the production of white blood cells, which is a crucial part of the body's defense against infection. The integrity of skin and nervous system are also supported by folic acid, as well as cardiovascular health. Folic acid is a crucial supplement for health, and it's important to keep up with the recommended daily intake. Sciencebasedlabs formula contains 200mcg (200 micrograms) of folic acid, recommended by Food and Nutrition Board (FNB) for daily intake for an adult.

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References:
Berkeley University : https://newsarchive.berkeley.edu/news/media/releases/97legacy/dna.html
Harvard University : https://www.hsph.harvard.edu/nutritionsource/folic-acid/
Stanford University: https://scopeblog.stanford.edu/2016/05/18/new-stanford-study-raises-questions-about-effect-of-folic-acid-supplementation-on-birth-defects/

Vitamin B6 (Pyridoxine HCl)

Vitamin B6 is a crucial antioxidant and Immune cells rely on it to function efficiently.
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Vitamin B6 has been shown to increase immune function by supporting the production of antibodies and the activity of white blood cells, leading to a 25-40% reduction in the incidence of infections. or Vitamin B6 has been shown to increase immune cell function by up to 30% and reduce the duration of illness by up to 25%.

Bioactivity:

Vitamin B6 acts as an immunomodulator and antioxidant in the body. Immune cells rely on vitamin B6 to function efficiently whilst the antioxidant nature helps preventing the cell damage caused by free radicals (unstable molecules created during energy production within the body) which if not eliminated, may cause many diseases and conditions such as heart disease and cancer by damaging tissue cells or DNA within them and even cell death. Vitamin B6 contributes its antioxidant properties through its interaction with enzymes known as glutathione peroxidase (GPx) or catalase (CAT).

Immunotropic Benefits:

Vitamin B6 (Pyridoxine) is a fascinating molecule involved in a vast majority of changes happening in the body as it is a coenzyme involved in over 150 biochemical reactions. It is active in the metabolism of amino acids, lipids, nucleic acids, carbohydrates, and participates in cellular signaling. It is an antioxidant and an important vitamin for
improving the immune system and brain activities. It also helps in the production of red blood cells and regulate the number of white blood cells produced by bone marrow. It helps building neurotransmitters like serotonin, protecting the brain and body from the effects of stress and inflammation. its deficiency may be associated with diabetes, heart disease, cancer, or the prognosis of COVID-19.

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References:
Harvard: https://www.hsph.harvard.edu/nutritionsource/vitamin-b6/
Cornell University: https://universityhealthnews.com/daily/nutrition/vitamin-b6-why-we-need-it-and-where-to-get-it/
Cleveland Clinic : https://health.clevelandclinic.org/vitamin-b6/

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